Woodolin (Luteolin),Natural Luteolin Powder, aka yellow flavin, yellow Shaling, is a species of natural flavonoids found in a variety of plants.Because originally from the woody rhinoceros family (Resedaceae) woody rhinoceros genus (Reseda) of the herb woody rhinoceros (English name Reseda, plant classification under the Latin name R.odorata L.) The leaves, stems, branches isolated, is a natural pigment component.It has a variety of pharmacological activities, such as anti-inflammatory, anti-allergy, anti-tumor, antibacterial, antiviral, etc., mainly clinically used for cough, expectorant phlegm, anti-inflammatory, treatment of cardiovascular disease, treatment of “atrophic lateral sclerosis”, SARS, hepatitis, etc
What is Woodolin
Woodolin, flavonoids present in many medicinal plants, is one of the most abundant secondary metabolites in plants and has various pharmacological activities.Woodolin (3,4,5,7-tetrahydroxyflavonoids) as a natural flavonoids in a variety of vegetables, fruits and medicinal plants, including broccoli, onion leaves, carrots, peppers, cabbage, apple peel, and chrysanthemums
Woodolin is reported to have antioxidant, microbial, anti-inflammatory, chemoprophylaxis, chemical therapy, cardiac protection, anti-diabetic, neuroprotective and anti-allergy properties
Natuluteolin extract manufacturer
kangyuan Natural is a wholesale bulk supplier of Luteolin.
What is Natural Luteolin Powder
Xhinin is a natural tetrahydroxylavone compound
It is widely found in vegetables and fruits, such as celery, broccoli, chrysanthemum, carrots, pepper, cabbage, apple peel, and onion leaves
In celery, green pepper, Perilla, and chamomile, lignin often occurs in the glycile form
Inhibition of tumor cell proliferation
The inhibitory effect of xyrhinoxin on tumor cell proliferation is mainly by inhibiting the activity of certain kinases in the cell and blocking the cell cycle
antioxidant
Reactive oxygen species is a class of oxygen content that is directly or indirectly transformed from molecular oxygen species and has a more lively chemical reactivity than molecular oxygen species.Normally the body can maintain the ROS within a certain range, but when affected by inflammation, chemical reagents, radiation, etc., the balance is broken and the ROS continues to rise.Excessive ROS can cause damage to DNA, liposomes, proteins, etc., leading to the occurrence of diseases such as malignant tumors
antiinflammatory
The anti-inflammatory activity of lignin is mainly manifested in its reduced activity of transcriptional regulators of inflammatory factors and reduced the production of pro-inflammatory cytokines and inflammatory mediators
neuroprotective effect
Microglia are immune response cells of the central nervous system that constantly remove damaged nerves, plaques, and infectious substances in the CNS.
When stimulated by pro-inflammatory stimulators such as lipopolysaccharide (LPS) in the cell wall of Gram-negative bacteria, the microglia are able to be activated to produce large amounts of cytokines and reactive oxygen species that damage various types of neurons in the central nervous system
What is the composition of rhinoceros
Xhinin is a natural flavonoid
Usually found in the glycosylated form in a variety of medicinal materials, vegetables and fruits, such as honeysuckle, Jing mustard, violilla, cabbage, broccoli, carrots and pomegranate [1].Woodolin has pharmacological effects such as anti-tumor, antioxidant, anti-inflammatory, anti-allergy, antibacterial, antiviral, neuroprotection, and cardioprotection
However, poor water and lipid soluble and poor bioavailability greatly limited its clinical use
What is The chemical structure of lignolin
What is Structure of lignolin
Xhinins are flavonoids, yellow needle crystals, molecular formula C15H10O6, molecular weight of 286.23, melting point 228℃~230℃, chemical name 3 ′, 4 ′, 5,7-tetrahydroxylavone
The lignolin mother nucleus is composed of 15 carbon atoms arranged in a C6-C3-C6 configuration, interconnected by two C3 with phenolic hydroxybenzene rings through the center
According to the principle of “similar phase dissolution”, xyrhinolin free glycosides are easily soluble in organic solvents such as methanol, ethanol, acetic ether, n-butytanol, acetone and acetyl acetate, as well as dilute alkali aqueous solutions.Woodolin is a strong planar molecule that is difficult to dissolve in water because of its close arrangement between molecules and molecular molecules and large gravity
Luteolin Powder antibacterial activity
Wood rhinolin can inhibit a variety of bacteria and viruses, such as Staphylococcus aureus, Bacillus subtilis, E. coli, herpes simplex virus, poliovirus, corsacki B3 virus, etc
It has an obvious bacteriostatic activity, and its antibacterial mechanism is mainly realized by inhibiting the activity of DNA topoisomerase, and then affecting the synthesis of bacterial nucleic acid and protein
Luteolin Powder antopxidation
Modern medical studies show that many diseases of life phenomena are closely related to the formation of free radicals, such as the excessive accumulation of free radicals in the body may cause aging, cancer, cardiovascular disease, etc.Flavonoids such as lignin are reducing because they contain unsaturated double bond, phenol transgroup or reducing miscellaneous atoms, and the removal of human radicals, the main mechanism is to generate a more stable semi-roller radical through the reaction of phenol hydroxyl group and free radicals, so as to terminate the radical chain reaction
Luteolin Powder Anti-inflammatory effects
Woodolin from histology inhibited lung tissue inflammation and the inhibition of specific antibody growth to Chlamydia pneumoniae in lung tissue
Luteolin Powder Anti-tumor effects
Induction of apoptosis in tumor cells is an important mode of action of anti-tumor drugs, and the mechanisms of action are many and very complex
Luteolin Powder Reduce blood lipid and cholesterol and improve immune function
The effect of left ventricular cardiomyocyte contraction function and the effect of xyrhinolin on necrosis and apoptosis after myocardial ischemia and reperfusion revealed that lignolin could prevent ischemia-reperfusion damage by reducing necrosis and apoptosis in rat cardiomyocytes.
Luteolin Powder Exmethod of peanut shell flavonoids
The preparation methods of thick peanut shell extract include: solvent extraction method, ultrasonic assisted extraction method, water bath reflux method, microwave auxiliary method, ultra-high pressure method, supercritical extraction method, hot water extraction method, alkaline water solution or alkaline dilute alcohol extraction method, etc
What is the effect of Luteolin Powder
Woodolin, flavonoids present in many medicinal plants, is one of the most abundant secondary metabolites in plants and has various pharmacological activities.Woodolin (3,4,5,7-tetrahydroxyflavonoids) as a natural flavonoids in a variety of vegetables, fruits and medicinal plants, including broccoli, onion leaves, carrots, peppers, cabbage, apple peel, and chrysanthemums
Woodolin is reported to have antioxidant, microbial, anti-inflammatory, chemoprophylaxis, chemical therapy, cardiac protection, anti-diabetic, neuroprotective and anti-allergy properties
Multiple pharmacological activities of Rhinolin have been confirmed to be associated to its anti-inflammatory effects.Meanwhile, Chinese medicine containing high wood rhino content has been used in Iran and Brazil to treat inflammation-related diseases
Natural-derived compounds are usually part of the lead compound.In fact, there are over 100 derived drugs with natural products currently in clinical trials
Luteolin Powder Woodolin inhibits inflammation
Early inflammation of atherosclerosis (Atherosclerosis,AS) stimulates endothelial cell activation, with monocytes attached to endothelial cells Macrophages, eventually becoming the marker cell —— foam cells of lipid-rich AS.Multiple adhesion molecules (ICAM-1, VCAM-1) and chemokines (MCP-1, IL-8) regulated by TNF-α are critical mediators of endothelial cell
monocyte adhesion, both of which harbor [3] in the AS inflammatory response.NF-κB is a pro-inflammatory transcription factor characterized by regulating the expression of the above molecules.The pathogenesis of AS is largely related to [4] and TNF-α activation, which promotes NF-κB activation
Luteolin Powder Woodolin inhibits oxidative stress
Actipoactive oxygen species (reactive oxygen species,ROS) causing tissue damage through oxidative stress is involved in the pathological process of AS.Many flavonoids (e. g. lignin) are able to clear ROS to inhibit AS development.
What is Physiological function of lignolin of Luteolin Powder
BenRhinin (Luteoin), is an effective ingredient isolated from effective whole-leaf green orchid (Dracocephalum integrifolium Bge.) in Xinjiang as well as white paraquat (Ajugadecumbens Thunb) produced in Anhui.Like other subclass pigments, flavonoids also have the functions of sterilization, anti-inflammatory and convergence
In addition, it also has a pharmacological function of vitamin P (Vitamin P).Its natural products have been applied in clinical treatment of cough, expectorant, phlegm, anti-inflammatory, has a good effect ¨
Luteolin Powder Prevention and treatment of liver fibrosis effect
It was also observed that Lu reduced collagen mRNA expression before hepatic type I and significantly reduced MDA content, but MMPs activity was not altered.Conclusion: Lu removes free radicals and suppresses collagen gene expression, and prevents liver fibrosis in animals.
Luteolin Powder Isolation and extraction of rhinhinins
Rhinolin was performed best on a polyamide chromatography column with 70% ~ of 75% ethanol; xyrhinolin in peanut shell methanol extract was present in completely free form.
Luteolin Powder Semi-synthesis of lignolin
Due to the low extraction rate of natural products and some difficulties in clinical application, the synthesis and chemical structure transformation of such compounds have become a hot topic in recent years
lignolin was semi-synthesized from tangerine peel, with a total yield of 35%.
On the basis of previous research, a new synthetic route through oxypicine hydrolysis, demethyl, dehydrode three-step xyrhinolin, whose total yield of 45.9%, but also using this method with better yield to semi-synthesize pharmacological active dihydroflavonoids: oxypicin and holy polyphenols [
Luteolin Powder How is rhinoceros extract extracted
Trichotaxin is a natural flavonoids with yellow needle crystallization, melting point of 228~230℃, molecular formula C15H10O6, molecular weight of 286.24, lignolin in the chemical name 3 ‘, 4’, 5,7 tetrahydroxylavone, widely exists in many plants in nature, lignolin-rich plants are often used to treat diseases, with a variety of pharmacological effects
Luteolin Powder solvent-extraction process
Solvent extraction method is according to the dissolution nature of various ingredients in Chinese herbal medicine in the solvent, to choose the active ingredient solvent with large solubility and small solubility of dissolved ingredients, so as to dissolve the effective ingredients from the tissue of medicinal materials.Zhou Jianxin and others are the best to extract lignone through different solvents, followed by ethanol, methanol is slightly lower than ethanol, because acetone and methanol are somewhat harmful to the human body, so relatively safe ethanol is generally chosen as the solvent to extract lignin.
Luteolin Powder Ultrasound adjunct
The principle of ultrasound is mainly the destruction of the cell membrane using the cavitation of ultrasound, which contributes to solute diffusion
Luteolin Powder Supercritical fluid extraction method of Luteolin Powder
Critical fluid extraction is a technique for extracts certain effective components from a solid or liquid using supercritical fluid as a solvent.This method highly breaks the plant cell wall, increasing the contact area of flavonoids and the solvent and the extraction channel
Luteolin Powder Microwave auxiliary method
Microwave extraction principle is microwave radiation leads to polar substances, especially water molecules to absorb microwave energy and produce a lot of heat, liquid water gasification pressure from the break through the cell membrane and cell wall, cell interior and cell wall water reduction, cracks, extracellular solvent into the cell, dissolve and release the intracellular substances
Luteolin Powder Enzyme adjunct
Most active ingredients of plants are included in plant materials (such as cell wall, pectin, etc.), and in the enzyme in plant extraction can degrade plant materials to form an evacuation structure, and sometimes even completely dissolve plant materials to achieve the highest extraction rate
What can rhinoceros extract do of Luteolin Powder
Xorhinolin shows yellow needle crystallization with a melting point of 228℃~230℃, a formula C15H10O6, molecular weight of 286.24 and a chemical name of 3 ′, 4 ‘, 5,7 tetrahydroxylavones (3 ′, 4’, 5,7 Tetralydroxyflanone).Because originally from the family Xerocidaceae (English name Reseda, Latin name R.odorata L.) Leaves, stems, branches separated from the name, is a natural pigment component.It can be soluble in methanol, ethanol, acetic ether and other organic solvents and alkaline solutions, slightly dissolved in hot water, dissolved in concentrated sulfuric acid to produce zinc salt, which is dark red and yellow.
