Osthole Powder, Snake bed is the dry, ripe fruit of the annual herb snake bed (Cnidiun mon— nieri (L.) Cusson) in Umbrella aceae, sweet, bitter and warm.
The kidney meridian, has the effect of warm kidney aphrozhuang sun, loose cold dispel wind, dry and wet insecticide.Clinical use is mainly external, mostly used for the treatment of surgery, gynecology, skin diseases.
Recent studies on the effective components of snake beds have focused on coumarins, separating six monomers from total coumatines, including snake bed (Osthol,Ost), bergamot lactone (Bergapten), isocyanin (Isopimpinelliu), pepper toxol (Xouthotox01), pepper toxin (Xouthotoxin), parsley B (Im— peratoriu).Snake bed has the highest content, accounting for about 60% of the total coumarin.
Serptonin, aka methoxyparhenol (osthole,Ost), is a coumarin compound extracted from the fruit of the snake bed in the family, named 7-methoxy-8-isprenyl coumarin, which is an effective chemical component with the highest content (about 1%) in the snake bed.Its pharmacological effects are extensive and have on the nervous system, cardiovascular system, immune system and so on.
What is Snake bed (Fructus Cnidii) Osthole Powder
Snake bed (Fructus Cnidii) is a snake bed in the family Parmbaceae [Cnidium monnieri (L.）Ｃｕss.] Dry and ripe fruit, alias wild carrot, snake rice, wild fennel
What can Osthole Powder do
Snake bed medicine xin, bitter, warm, with small poison, kidney, its effect is insecticide and itching, dry damp wind, warm kidney aphrodisac, mainly used in pussy wet itching, eczema, scabies; cold and wet belt, wet Bi and low back pain, kidney deficiency and impotence, uterine infertility.
“Shennong Materia Medica” said: ” the master man is impotence wet itching, the woman Yin swelling pain, in addition to Bi qi.”Modern clinical snake bed is mainly used, mainly used in surgery, gynecology and dermatology
In recent times, more research has been done on the main potent component of snake bed protein in snake bed. At present, the application of snake bed protein has a good therapeutic effect on
in treating diseases of cardiovascular and cerebrovascular system, nervous system, endocrine system and immune system.Serpectin, also known as methoxyparparhenol, has the highest content of coumarin in snake beds.
Pharmacological research has shown that serpectin has anti-arrhythmia, anti-thrombosis, anti-osteoporosis, anti-inflammatory, anti-oxidation and hormone-like effects
Heart and brain vasculature of Osthole Powder
Cardiovascular and cerebrovascular diseases are systemic vascular lesions or systemic vascular lesions in the heart and brain, with high incidence, high disability rate, high fatality rate, high recurrence rate, complications, most of cardiovascular and cerebrovascular diseases drugs lack tissue specificity, and short half-life, seriously limited the clinical drugs
We have found that it relieves vasodilation, reduces blood pressure, and protects the heart and circulatory system.In atherosclerosis and postangioplasty restenosis, the proliferation of vascular smooth muscle is a key factor, and the treatment with serptonectin can selectively inhibit the proliferation of vascular smooth muscle, so as to achieve the effect of protecting the heart
cerebrovascular disorder of Osthole Powder
Stroke is a common cerebrovascular disease in the elderly, but also the main cause of death and permanent disability, the main form of expression is ischemic stroke.It was found that in the establishment of rat central cerebral artery occlusion / reperfusion (MCAO/R) model, the development of rat cerebral infarction, hippocampal neuronal injury and apoptosis resulted on the activation of the Notch signaling pathway
, Following administration of serpectin in a mouse model of corticostab trauma, apparently improved mouse neurofunction, reduced infiltration of macrophages / microglia and neutrophils and reduced levels of inflammatory cytokines, suggesting that serpectin reduces the occurrence of brain injury after neurosurgery by inhibiting inflammation and apoptosis
systema nervorum centrale of Osthole Powder
Serptontin has therapeutic effects on CNS degenerative diseases such as Alzheimer’s, Parkinson’s disease, etc.Parkinson’s disease is a common central nervous degeneration disease in the elderly. After the onset, dopamine synthesis at the nigra is reduced, thus inhibiting the reduced function of acetylcholine, showing the imbalance between acetylcholine and dopamine, resulting in tremor paralysis
Mechanical brain injury is a common neurological disease in the central nervous system, with high lethality and disability. In the case of mechanical brain damage, neuronal death leads to loss of neurological function, and there is no more effective way to restore neurological defects caused by mechanical injury
endocrinium of Osthole Powder
Anti-female postmenopausal osteoporosis is a systemic bone disease, one of the most common metabolic diseases, mainly characterized by low bone mass and microstructural degeneration of bone tissue as well as bone fragility and fracture susceptibility
Hormone-like action of Osthole Powder
Snake beds have hormone-like effects
, In a mouse model of genogenic damage caused by cyclophosphamide, serptin administration increased serum testosterone and increased expression of the androgen receptor, showing androgen-like effect
anti-inflammatory effect of Osthole Powder
In a rat model of inflammation prepared with keratgum, the mechanism of action may be correlated with the activity of nitric oxide (NO), M D A and constructive nitric oxide synthase (cNOS) by inhibiting calcium influx and increasing cGMP levels and is dose-dependent
Anti-allergic effects of Osthole Powder
It was found that snake bed has some therapeutic effect on contact dermatitis caused by dinitrofluorobenzene (DNFB) and bitter grass (PC).The study showed that after using 70% ethanol and using DNFB and PC, the results showed that it could significantly inhibit scratching behavior and was dose-dependent, indicating that sercotin had an anti-allergic effect and can be used to treat allergic diseases
Serpectin was found to inhibit proliferation of hepatoctomas (HCC), induce cell cycle arrest, trigger DNA damage and inhibit HCC cell line migration.Serptonectin suppresses the migration of HCC cell lines by downregulating MMP-2 and MMP-9 levels, while, also inhibiting epithelial stromal transformation (EMT) and significantly reducing the expression of mesenchymal N-cadherin and vimentin
What effect does Osthole Powder have
Snake bed [Cnidium monnieri (L.)Cuss.] The fruit of the annual herb snake bed in the family Umbrella aceae.The Compendium of Materia Medica records that the snake bed is “bitter, flat and non-toxic”.Snake bed contains complex chemistry, in which bed is the main active ingredient of snake bed.Modern studies have found that serptin has significant roles in treating hypertension, lowering blood lipids, antiarrhythmia, antitumor and anti-osteoporosis
What is Osthole Powder
Serpetin is the first coumarin compound found in Peucedanum ostruthium in 1909, mainly in the Parachinaceae and Brassaceae.It is also found in a few species of inaceae and legaceae. In the umbrella plant snake bed fruit is higher than 1% with the chemical name 7 one methylgroup 18 one prenyl coumarin with a molecular weight of 244.29t
What is Chemical structure of Osthole Powder
Snake bed element (dry ze thief bath dry algae, rhyme ze thief), also known as methoxy parsley, chemical name is the original methamyl coumarin (garden original soap algae thief bath dry gave the original wish [ape soap algae thief zao give blame algae stove thief original round original algae stove gift] bad dry how soap buried flea stove), molecular formula is: Yue Yuan Yuan Yun ape, molecular weight is the round source source aid round resentment
In vitro antitumour mechanisms
With the further study of the anti-tumor activity of snake bedtin, the in vitro anti-tumor activity and its mechanism are further clarified, which may achieve the anti-tumor effect: inhibiting tumor cell proliferation; affecting the tumor cell cycle; inducing tumor cell apoptosis; reversing tumor cell resistance; and synergistic chemotherapy drugs
Inhibition of tumor cell proliferation of Osthole Powder
Cell proliferation (poor algae) refers to the process of cell division and regeneration. Tumor cell proliferation is different from normal cell proliferation lies in unlimited division, invasion of other tissues, and eventually leads to host death.Inhibition of tumor cell proliferation is the most direct effect of antitumor agents
Influect tumor cell cycle of Osthole Powder
Cellular cycle (dysplasia) is the cycle process where eukaryotic cells grow after one mitosis to the end of the next division.Disordered cell cycle disorder is a central link of genomic instability that increases the likelihood of further cancer of unstable cells
Induction of apoptosis in the tumor cells of Osthole Powder
Apoptosis (funeral death) refers to the orderly death of cells controlled by genes to maintain the stability of the internal environment.Apoptosis is algae is taught in the Yuan year according to morphological characteristics [roun].Tumorigenesis or failure of anti-tumour treatment is closely related to abnormalities of apoptotic mechanisms
Reverse tumor cell resistance of Osthole Powder
Tumor cells drug resistance is more, among which multidrug resistance (how to soap how thief flea Juan chisel how early algae ze flea Ze thief buried stove bad algae, brew read hit) is more common.The resistance of tumor cells is one of the main causes of clinical tumor chemotherapy failure, so the search for efficient and low-toxic resistance reversals has become one of the new hot spots in the field of tumor drug development
Synergy and efficiency is commonly used as chemotherapy drugs of Osthole Powder
Chemotherapy of malignant tumors is one of the most commonly used treatment methods for the treatment of tumor drugs today.At present, the pursuit of efficient, low toxicity and a wide range of therapeutic targets is one of the hot points of chemotherapy
Reproductive system protection effect of Osthole Powder
Based on the effect of “warming husband Yang and helping women Yang” contained in the Compendium of Materia Medica, modern research has found that snake bed is conducive to the repair of reproductive endocrine function
Anti-osteoporosis in snakes of Osthole Powder
Subwarm fill.Kidney meridian, benefit the life door.Based on traditional Chinese medicine “.Kidney bone ” theory, modern research found that serpectin has strong bone and anti-osteoporosis effect.In the castration rat model of osteoporosis, compared with E.In contrast, serptonectin significantly reduces urinary deoxypyridine phenol (DPD) and reduces bone loss
The early stages of serptonectin-induced differentiation of secreted osteocalcin-mediated osteoblasts undergo the p38 kinase pathway of bone morphogen protein 2 (BMP 12), and later stages are associated with the 1 / 2 kinase pathway of extracellular signal-regulatory kinase (ERK)
Central nervous system protection effect
The theory of traditional Chinese medicine believes that tonifying kidney can improve the brain, and snake bed has also been found to have a protective effect on the central nervous system.
Alzheimer’s disease (AD) is characterized by the deposited amyloid mouth protein (AP) and the loss of neurons.Neural are derived from proliferation and differentiation of neural stem cells (NSC) into neurons.Serptontin enhances NSC proliferation and differentiation through activation of wnt distilled ~catenin signaling, suppresses apoptosis and reduces mail protein expression
The ammonia damage model is a very useful cellular model to evaluate the neuroprotective effects of drugs in neuropsychiatric disorders.
Time course studies of anticonvulsant effects revealed that sercotin in the mouse maximum electroconvulsive epilepsy model could produce a clear antiepileptic effect in mice with a ED50 of 259~63l mg/kg
In the theory of “removing evil sores” contained in this Bible, modern research has found that serptonectin has a good antitumor effect.In animal experiments
Oxidative stress response is the major mechanism of ischemia-reperfusion injury.With decreased serum SOD activity and promalaldehyde in mice after intestinal ischemia and reperfusion injury, serpectin improved s0D activity and significantly inhibited increased levels of IL 1 and TNF—a in mouse serum and decreased IL 12 in serum
Exidural administration of serptonin significantly reduced the mechanical pain threshold (50%MwT) in rats, and early postoperative application of serptonin had obvious analgesic effect on seroinflammatory pain caused by the nucleus mededullary, possibly by inhibiting phosphate kinase (pERK) activation, thus down regulating C0x (2 mRNA expression
What is the chemical composition of Osthol
The snake bed mainly contains bioactive coumarin compounds
Snake bed contains coumarin compounds: snake bedin , bergamot lactone , heterokolin, Colombian oltone (ArAngelica et al.
Sercotin significantly enhances the hypnotic effect of subthreshold hypnotic doses of sodium pentobarbitital on mice, and can also counter the increased number of autonomous activity in mice caused by small doses of Ann sodium coffee excited cerebral cortex
Improve learning memory and anti-aging
It was found to significantly improve memory acquisition and consolidation impairment and direction discrimination disorder, and to prolong the duration of scaffold hypoxia tolerance, but it had no obvious improvement effect on memory reproduction impairment.