Goji Fruit Powder
What is lycium barbarism L and what is Goji Fruit Powder
Lycium barbarum is a traditional medicinal plant in China. Its fruit is Lycium barbarum, belonging to Lycium
(Lycium), mainly including Ningxia Lycium barbarum L. and Chinese Lycium barbarum ly cium chinense Mill．。
What is Lycium barbarum L．and Lycium chinense Mill Goji Fruit Powder
Ningxia Lycium barbarum L. is a perennial deciduous shrub of Solanaceae. Its dry and mature fruit Lycium barbarum L. is not only a traditional precious traditional Chinese medicine in China, but also one of the homologous varieties of medicine and food published by the Ministry of health. It has been used in China for more than 2000 years.
It is sweet in taste and flat in nature. It has the function of nourishing the liver and kidney and benefiting the body. In the compendium of Materia Medica, Li Shizhen, a pharmacist in the Ming Dynasty, summarized the previous understanding of Lycium barbarum, “picking Lycium barbarum leaves in spring, named Tianjing grass;
picking flowers in summer, named perennial grass; picking fruits in autumn, named Lycium barbarum; picking roots in winter, named pericarp”. It was also pointed out that there were significant differences in sexual and flavor functions due to different medicinal parts of Lycium barbarum.
Modern medical, nutritional and pharmacological studies have found that Lycium barbarum fruit, leaves and roots contain polysaccharides, amino acids, vitamins and trace elements needed by human body, which has high medicinal and nutritional value.
With the rapid development of China’s economy and the enhancement of people’s awareness of health care, the health care and medicinal value of Lycium barbarum are increasing It has been paid attention to, the market price has increased steadily, and medlar has strong adaptability. It is especially suitable for planting in saline alkali land and returning farmland to forest land, making it an important cash crop in Northwest China, and even a pillar crop in some places The prospect of industrial development is very broad
What are the main ingredients of Lycium barbarum of Goji Fruit Powder
The main components of Lycium barbarum include Lycium barbarum polysaccharide, flavonoids, carotenoids, betaine and cerebroside ( cerebroside) 、 β － Sterols（ β － Sitosterol), amino acids Vitamins, trace elements, etc
What is Lycium barbarum polysaccharide of Goji Fruit Powder
Lycium barbarum polysaccharide is considered to be the most important component of Lycium barbarum to exert biological effects, and many studies have been carried out It is confirmed that Lycium barbarum polysaccharide has many effects, such as anti-oxidation, anti-aging, anti-tumor, immune regulation, neuroprotection, liver protection, hypoglycemic and so on
What are flavonoids of Goji Fruit Powder
Flavonoids are another major component of Lycium barbarum Active ingredients, with antioxidant, anti-inflammatory, anti angiogenesis, hypolipidemic and other effects, carotenoids mainly include zeaxanthin and β － Carotene, a study found that corn Yellow has certain protective function in liver injury and diabetic retinopathy.
What is betaine of Goji Fruit Powder
In addition, betaine was also found to have antioxidant and liver protective effects
Why does Lycium barbarum have antioxidant and anti-aging effects of Goji Fruit Powder
Aging is a continuous degradation of physiological function, and organ function damage is sensitive to disease A process of increase, based on the free radical theory of aging, aging and oxidative damage of cells Injuries are inseparable.
As a natural antioxidant, Lycium barbarum polysaccharide has antioxidant and anti-aging properties
The role of the old.
At the cellular level in vitro, human umbilical vein induced by angiotensin II It was found that Lycium barbarum polysaccharide could be down regulated by endothelial cell replicative aging The expression of p53 and p16 promotes cell proliferation and delays cell aging
At the overall animal level, the animal models used for aging research mainly include fruit flies, zebrafish and mice
Rats. It has been found that Lycium barbarum polysaccharide can significantly prolong the fruit rope or not The average life span of mice, but had no effect on the maximum life span of both
Mice and rats were used as animal models It is found that Lycium barbarum polysaccharide can inhibit natural aging, STZ, high-fat diet, hypoxia and exercise-induced oxidative stress
Why does Lycium barbarum have immunomodulatory effect of Goji Fruit Powder
The immunomodulatory function of Lycium barbarum polysaccharide is one of the most important biological functions of Lycium barbarum One more aspect.
At the cell level in vitro, Lycium barbarum polysaccharide can promote T cells, B Cells, macrophages, natural killer cells (NK cells) and dendritic cells (DC cells) Proliferation and activation of
Therefore, Lycium barbarum polysaccharides play an important role in immune and inflammatory response Adjustment function. At the overall animal level, it was found that mice were injected intraperitoneally for 6 consecutive days one hundred μ G / ml Lycium barbarum polysaccharide glycogen can significantly promote the proliferation of splenocytes
It can induce IL-6, IL-8, IL-10 and tnf-1 in splenocytes in a concentration dependent manner α of produce
In addition, studies have shown that Lycium barbarum polysaccharide and Chlamydia vaccine are mixed together Injection of mice can significantly induce higher antibody level and higher IFN – γ And IL-2, so that a stronger Th1 immune response occurs in the mouse spleen to clear the branches Protoplasm
Why does Lycium barbarum have antitumor effect of Goji Fruit Powder
Lycium barbarum polysaccharide can also inhibit liver cancer in mice HTERT protein expression and telomerase activity decrease the growth of transplanted liver cancer in mice Play an inhibitory role. These results suggest that Lycium barbarum polysaccharides also have significant effects at the overall animal level Inhibition of tumor growth and metastasis
Why does Lycium barbarum have the effect of reducing blood sugar and blood lipid of Goji Fruit Powder
Hypoglycemic effect of Lycium barbarum polysaccharide The effect is by promoting islets β Cell proliferation and increased glucose absorption.
At the animal level, animal models for diabetes research are mainly streptozotocin.(STZ) or alloxan induced model, high fat induced model, spontaneous diabetes Disease model, etc
After 4 weeks of oral administration of wolfberry polysaccharide, the blood glucose level of rats with type II diabetes induced by high-fat diet plus STZ was significantly reduced, and the level of insulin in serum increased, the level of MDA and NO decreased, and the level of SOD increased. This indicates that Lycium barbarum polysaccharides may improve glucose metabolism by inhibiting oxidative damage.
Why does Lycium barbarum have hepatoprotective effect of Goji Fruit Powder
Liver protecting effect is one of the most studied aspects of the biological function of Lycium barbarum polysaccharide. Chinese wolfberry Lycium barbarum polysaccharides mainly reduce oxidative stress injury, inhibit inflammatory response and inhibit hepatocytes Apoptosis to protect the liver from all kinds of damage
The models used for this functional study mainly include alcoholic fatty liver, nonalcoholic fatty liver or chemical induced acute liver injury
In nonalcoholic fatty liver, Lycium barbarum polysaccharide can selectively activate AMPK α 2. Enhance mitochondrial biosynthesis and mitochondrial autophagy, so as to inhibit the formation of fatty liver
Why does medlar have eye protection of Goji Fruit Powder
It has been recorded since ancient times that Lycium barbarum has the effect of “brightening eyes and calming nerves”. At the cellular level in vitro, Lycium barbarum has a protective effect on retinal pigment epithelial cell ARPE-19. Studies have shown that Lycium barbarum extract or taurine, an important component of Lycium barbarum, can protect ARPE-19 cells induced by high glucose by inhibiting caspase dependent apoptosis
It was found that Lycium barbarum polysaccharide could not delay sudden degradation, but could delay secondary degradation. It played a protective role by inhibiting oxidative stress, JNK signal pathway and instantaneously increasing the content of IGF-1
Why does medlar have neuroprotective effect of Goji Fruit Powder
Lycium barbarum polysaccharide has neuroprotective function in a variety of in vitro and in vivo models. For example, at the cellular level in vitro, Lycium barbarum polysaccharide can inhibit 6-hydroxydopamine (6-OHDA) – induced apoptosis in PC12 nerve cells
A was injected into bilateral hippocampus β In the AD rat model established by 1-40, LBP can also improve the learning and memory function of AD rats by increasing the activity of SOD and GSH PX in hippocampus, reducing the content of MDA and enhancing the expression of BrdU positive cells in dentate gyrus
What effect does medlar extract have of Goji Fruit Powder
At present, in addition to the above main functions, many studies also found that Lycium barbarum polysaccharide also plays an important role in protecting cardiovascular system, reproductive system, intestinal system, kidney, anti radiation, anti fatigue, anti osteoporosis and so on. Therefore, as a natural antioxidant, Lycium barbarum polysaccharide plays an important protective role in redox regulation, metabolic regulation, immune regulation, tissue and organ protection and so on
What’s the name of Lycium barbarum of Goji Fruit Powder
Lycium barbarum has various common names, such as Lycium barbarum L, Lycium halimifolium (Lycium vulgar), Lycium turcomanicum Turcz, yellow jasmine, box throne, common matrimony vine and tea Plant, tea tree). Its dry roots are called pericarp.
What is Lycium barbarum polysaccharide of Goji Fruit Powder
The most studied component in Lycium barbarum fruit is water-soluble Lycium barbarum polysaccharide (LBP), accounting for 5% ~ 8% of dry fruit, and the molecular weight of LBP is 8 ~ 241 Ku.
Luo and others used DEAE cellulose ion exchange method, gel permeation chromatography and high performance liquid chromatography to separate and purify several kinds of Lycium barbarum polysaccharides from aqueous extract of Lycium barbarum. The structures were analyzed by gel electrophoresis, gas chromatography, amino acid auto analysis, acid hydrolysis, gas chromatograph mass spectrometry (GC-MS), high resolution electrospray ionization mass spectrometry (HRESIMS), Analysis of one-dimensional and two-dimensional NMR
What is medlar extract of Goji Fruit Powder
For Lycium barbarum extract and products, polysaccharide content is the key to the efficacy of Lycium barbarum. Traditional Chinese medicine has found many bioactive polysaccharides derived from plants and fungi with a variety of immune activities.
The content of polysaccharides ，Goji Fruit Powder with pharmacological activity is considered to be an index of the medicinal grade of natural products.
What is carotenoid in Lycium barbarum extract ,Goji Fruit Powder
The orange red of Lycium barbarum fruit ，Goji Fruit Powder is colored by carotenoids, accounting for only 0.03% ~ 0.5% of the dry fruit
The saponified and unsaponifiable extracts of Lycium barbarum contain 11 kinds of free carotenoids and 7 kinds of carotene esters. Free carotenoids include β- Carotene β- Cryptoxanthin and zeaxanthin.
Carotenoid fatty acid esters are mainly zeaxanthin dipalmitate, zeaxanthin Monopalmitate and β- Cryptoxanthin palmitate. The main carotenoid is zeaxanthin in the form of esterification, accounting for 1 / 3 ~ 1 / 2 of the total carotenoids.
What is the physiological function of Lycium barbarum of Goji Fruit Powder
The physiological functions of Lycium barbarum ，Goji Fruit Powderinclude anti-aging, nerve protection, anti bone marrow suppression and improving sleep quality
For 14 ~ 30 days, eating standardized medlar juice (Gochi 120 ml is equivalent to 150 g of fresh fruit) ，Goji Fruit Powder， every day can enhance nerve, cardiovascular, joint, muscle function and gastrointestinal regularity without any side effects.
The study of the five groups found that there were significant differences between the pre and post dry expectations, which were effective in enhancing physique, improving sleep quality, promoting blood circulation, anti fatigue, improving attention and memory, reducing cold limbs and improving spirit.
Preliminary estimates of these effects were made and 63% of the subjects were improved. Randomized subjects, double-blind, placebo-controlled human clinical study, a total of 201 people, the average number of each subject is about 40. These improvements were confirmed by meta-analysis
Several randomized clinical studies have reported that Lycium barbarum juice standardized by Lycium barbarum polysaccharide (LBP) can significantly promote postprandial energy consumption than placebo.
Ingestion of Lycium barbarum can effectively control the waist circumference of the human body and may reduce the risk of metabolic syndrome. It can promote the metabolic rate by controlling the stimulation of adrenocortical hormone
Why does Lycium barbarum extract have immunomodulatory effect
Goji Fruit Powder
Many studies have shown that Lycium barbarum and Lycium barbarum polysaccharides have many advantages
Immune regulatory functions, including the activation of various immune cells
The latest research of traditional Chinese medicine shows that Lycium barbarum polysaccharide can enhance cellular interventional immunity and humoral immune response. For example, experimental animals took Lycium barbarum polysaccharide 5 ~ 10 mg / kg every day. After one week, it was found that the activity of T cells and natural killer cells increased.
The experiment of Chinese wolfberry on IgE reaction showed that the use of Chinese wolfberry fruit could reduce the antibody of allergic reaction, and its mechanism may be to promote CD8 + T cells and regulate cytokines
Why does Lycium barbarum extract ，Goji Fruit Powder have cardiovascular benefits
Two kidneys of mice with hypertension were tested in vivo clip mode. The results showed that LBP treatment significantly prevented the increase of blood pressure.
The aortic rings of rats incubated in vitro were treated with methyl blue or N-nitro-L-arginine methyl ester and LBP.
Existing research results show that Lycium barbarum carotene can quickly degrade nicotine in the blood, and after nicotine enters the human body, it will produce limb endings, vasoconstriction, accelerated heartbeat, increased blood pressure, faster breathing, promote platelet aggregation and cause cardiac vascular obstruction.
The revelation of this new function provides a new idea for using Lycium barbarum to develop anti nicotine functional food and other products
Why does Lycium barbarum extract and Goji Fruit Powder have antioxidant and anti-aging effects
Many diseases and symptoms are caused by free radical oxidation. Lycium barbarum has antioxidant effect. The intake of Lycium barbarum increased the serum antioxidant capacity by nearly 10% under normal conditions.
LBP can also improve the fragility and abnormality of erythrocytes in NIDDM patients, make them close to or completely return to normal state, and can be used as adjuvant therapy in NIDDM patients
Studies have shown that Lycium barbarum can improve the activities of superoxide dismutase (SOD) and catalase (CAT), enhance the total antioxidant capacity (TAOC), reduce the level of malondialdehyde (MDA), reduce the activity of creatine kinase, endogenous lipid peroxidation and oxidative stress caused by exhaustive exercise
Why does Lycium barbarum extract have anticancer and antitumor effects
Many studies have reported that LBP plays an anti-cancer role through immune regulation. LBP can prevent the onset of non-insulin-dependent diabetes mellitus in rats, or even reduce the risk of canceration.
The antitumor effect of Lycium barbarum polysaccharide is due to increasing the number of CD4 (+) and CD8 + T units of tumor infiltrating lymphocytes, so as to reduce immunosuppression and enhance the antitumor effect of immune system.
LBP significantly increased the number of CD4 (+) and CD8 (+) T cells in til compared with the control group.
In the control group, the number of dendritic cells decreased significantly in the tumor microenvironment, while LBP tended to increase the number of dendritic cells and B7-1 expression. LBP (10mg / kg) effectively reduced tumor mass and improved immune system
Why does Lycium barbarum polysaccharide extract have antibacterial effect
According to preliminary in vitro studies, Lycium barbarum extract has antibacterial effects on 17 kinds of bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Salmonella typhi, Salmonella paratyphi A to B, Salmonella typhimurium, Bacillus subtilis, Bacillus anthracis, Pseudomonas aeruginosa, dysentery bacilli (dysentery bacilli), Escherichia coli, Candida albicans and typhoid bacilli Considering the crude extract of raw materials and macromolecules, such as Lycium barbarum polysaccharide, its bioavailability is a key to its effect in vivo.
Preliminary antibacterial effect studies show that LBP can be used in gastrointestinal tract or surface. A typical antibiotic drug as a positive control needs to be compared under the same experimental system conditions. These are only preliminary studies, and follow-up studies need to further explore these effects
Why does Lycium barbarum extract ,Goji Fruit Powder have a protective effect on eyes
Carotenoids were found in all tissues of the eye. The contents of lutein and zeaxanthin are different in the fovea and surrounding areas of the retina. The content of lutein in the surrounding areas is the highest, while the content of zeaxanthin in the fovea is high.
Studies have shown that zeaxanthin and lutein have eye protection and are negatively correlated with senile degenerative macular disease. The disease occurs in the central macular region of the fundus retina, which is the most sensitive part of visual function.
Studies have shown that the retinal macula at the back of the center of the human retina is rich in antioxidant pigment, which is produced by high-density zeaxanthin and lutein.
Zeaxanthin and lutein,Goji Fruit Powder are the only carotenoids present in the macular region of the retina. Their intake from the diet can affect the macular pigment density. Regular consumption of foods rich in carotenoids, especially zeaxanthin and lutein, can reduce the possibility of senile macular degeneration.
Lutein ，Goji Fruit Powder and zeaxanthin supplementation can significantly improve aging macular retinopathy, at least early lameness, and reduce the risk of senile blindness.