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Cannabinoid (CBD) is a natural extract which has significant effect on many diseases. 104 kinds of natural active compounds can be extracted from hemp, mainly CBD and THC. THC can cause pleasure and hallucination, while CBD has no mental activity. Marijuana can be roughly divided into entertainment marijuana and industrial hemp, the latter is called hemp or hemp in China.
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Receptor systems involved in potential therapeutic applications of CBD
Although CBD does not really bind to either of the two cannabinoid receptors (CB1 and CB2), it does activate some non cannabinoid receptors. It also works through numerous channels that are completely independent of any receptor, for example, by causing delays in “reuptake” of internal neurotransmitters such as anandamide and adenosine.
It also enhances or inhibits the binding of specific receptors, such as G-coupled protein receptors.
Some of the ways in which CBD recognizes its multiple therapeutic effects are:
CBD and adenosine receptor
The anti anxiety and anti-inflammatory effects are mainly related to the activation of adenosine receptor. By stimulating adenosine, CBD promotes the release of dopamine and glutamate neurotransmitters.
Motor control, cognition, motivation and reward mechanism are related to dopamine release, while glutamate is involved in learning, memory formation, excitatory signal and cognition.
CBD and serotonin
But this is not all the functions CBD performs in the human body. It is also involved in stimulating the 5-HT1A serotonin receptor, which produces known antidepressant effects. The receptor is common in many other processes such as appetite, pain, nausea, anxiety and addiction mechanisms.
Last but not least, CBD has a tendency to reduce cancer cell proliferation and bone resorption by inhibiting GPR55 signaling.
GPR55 is dominant in the brain and is associated with important processes, such as controlling blood pressure, regulating bone mineral density and preventing cancer cell proliferation.
